G mycetin, Garamycin (gentamicin) dosing, indications, interactions, adverse effects, and more (2024)

  • abobotulinumtoxinA

    gentamicin increases effects of abobotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Aminoglycosides may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects. .

  • acebutolol

    acebutolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • aceclofenac

    aceclofenac increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • acemetacin

    acemetacin increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • acyclovir

    acyclovir and gentamicin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • albuterol

    albuterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • amikacin

    amikacin and gentamicin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

  • amiloride

    amiloride increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

  • amiodarone

    amiodarone will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • arformoterol

    arformoterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • aspirin

    aspirin increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • aspirin rectal

    aspirin rectal increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • aspirin/citric acid/sodium bicarbonate

    aspirin/citric acid/sodium bicarbonate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • atenolol

    atenolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • bazedoxifene/conjugated estrogens

    gentamicin will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

  • bendroflumethiazide

    bendroflumethiazide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • betaxolol

    betaxolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • bisoprolol

    bisoprolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • bumetanide

    bumetanide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • candesartan

    candesartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • capreomycin

    capreomycin and gentamicin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • carbenoxolone

    carbenoxolone and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • carboplatin

    carboplatin and gentamicin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • carvedilol

    carvedilol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • cefaclor

    cefaclor increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefadroxil

    cefadroxil increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefazolin

    cefazolin increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefdinir

    cefdinir increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefditoren

    cefditoren increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefepime

    cefepime increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefepime/enmetazobactam

    cefepime/enmetazobactam increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides.

  • cefiderocol

    cefiderocol increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefixime

    cefixime increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefotaxime

    cefotaxime increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefotetan

    cefotetan increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefoxitin

    cefoxitin increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefpirome

    cefpirome increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefpodoxime

    cefpodoxime increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefprozil

    cefprozil increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftaroline

    ceftaroline increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftazidime

    ceftazidime increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftazidime/avibactam

    ceftazidime/avibactam increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftibuten

    ceftibuten increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftizoxime

    ceftizoxime increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftobiprole medocaril sodium

    ceftobiprole medocaril sodium increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftolozane/tazobactam

    ceftolozane/tazobactam increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • ceftriaxone

    ceftriaxone increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cefuroxime

    cefuroxime increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • celecoxib

    celecoxib increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • celiprolol

    celiprolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • cephalexin

    cephalexin increases toxicity of gentamicin by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

  • cephaloridine

    cephaloridine and gentamicin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • chlorothiazide

    chlorothiazide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • chlorthalidone

    chlorthalidone and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • choline magnesium trisalicylate

    choline magnesium trisalicylate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • cisplatin

    cisplatin and gentamicin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • clarithromycin

    clarithromycin will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • clotrimazole

    clotrimazole will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • colistin

    colistin and gentamicin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • conjugated estrogens

    gentamicin will decrease the level or effect of conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

  • contrast media (iodinated)

    contrast media (iodinated) and gentamicin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

  • cyclopenthiazide

    cyclopenthiazide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • cyclosporine

    cyclosporine and gentamicin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

  • daxibotulinumtoxinA

    gentamicin increases effects of daxibotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Aminoglycosides may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects. .

  • deferasirox

    deferasirox, gentamicin. Other (see comment). Use Caution/Monitor. Comment: Acute renal failure has been reported during treatment with deferasirox. Coadministration of deferasirox with other potentially nephrotoxic drugs, including aminoglycosides, may increase the risk of this toxicity. Monitor serum creatinine and/or creatinine clearance in patients who are receiving deferasirox and nephrotoxic drugs concomitantly.

  • deflazacort

    gentamicin and deflazacort both decrease serum potassium. Use Caution/Monitor.

  • dichlorphenamide

    dichlorphenamide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • diclofenac

    diclofenac increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dienogest/estradiol valerate

    gentamicin will decrease the level or effect of dienogest/estradiol valerate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor. An alternate or additional form of birth control may be advisable during concomitant use.

  • diflunisal

    diflunisal increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • digoxin

    gentamicin will increase the level or effect of digoxin by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.digoxin increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dobutamine

    dobutamine and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • dopexamine

    dopexamine and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • dronedarone

    dronedarone will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • drospirenone

    drospirenone increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

  • elvitegravir/cobicistat/emtricitabine/tenofovir DF

    gentamicin and elvitegravir/cobicistat/emtricitabine/tenofovir DF both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • ephedrine

    ephedrine and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • epinephrine

    epinephrine and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • epinephrine racemic

    epinephrine racemic and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • eprosartan

    eprosartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • erythromycin base

    erythromycin base will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • erythromycin ethylsuccinate

    erythromycin ethylsuccinate will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • erythromycin lactobionate

    erythromycin lactobionate will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • erythromycin stearate

    erythromycin stearate will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • esmolol

    esmolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • estradiol

    gentamicin will decrease the level or effect of estradiol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

  • estrogens conjugated synthetic

    gentamicin will decrease the level or effect of estrogens conjugated synthetic by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

  • estropipate

    gentamicin will decrease the level or effect of estropipate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

  • ethacrynic acid

    ethacrynic acid and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • etodolac

    etodolac increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • felodipine

    felodipine will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • fenoprofen

    fenoprofen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • flurbiprofen

    flurbiprofen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • formoterol

    formoterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • fosphenytoin

    fosphenytoin will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • furosemide

    furosemide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • hydrochlorothiazide

    hydrochlorothiazide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • ibuprofen

    ibuprofen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ibuprofen IV

    ibuprofen IV increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. NSAIDs may decrease excretion of aminoglycosides; data only on premature infants.ibuprofen IV increases levels of gentamicin by decreasing renal clearance. Use Caution/Monitor. Interaction mainly occurs in preterm infants.

  • incobotulinumtoxinA

    gentamicin increases effects of incobotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Aminoglycosides may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects. .

  • indapamide

    indapamide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • indinavir

    indinavir will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • indomethacin

    indomethacin increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ioversol

    ioversol and gentamicin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

  • irbesartan

    irbesartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • isoproterenol

    isoproterenol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • ketoconazole

    ketoconazole will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • ketoprofen

    ketoprofen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ketorolac

    ketorolac increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ketorolac intranasal

    ketorolac intranasal increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • labetalol

    labetalol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • letibotulinumtoxinA

    gentamicin increases effects of letibotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Aminoglycosides may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects. .

  • levalbuterol

    levalbuterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • levoketoconazole

    levoketoconazole will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • loratadine

    loratadine will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • lornoxicam

    lornoxicam increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • losartan

    losartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • magnesium supplement

    magnesium supplement, gentamicin.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Each enhance the neuromuscular blocking effect of the other; may have negative respiratory effects.

  • meclofenamate

    meclofenamate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • mefenamic acid

    mefenamic acid increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • meloxicam

    meloxicam increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • mestranol

    gentamicin will decrease the level or effect of mestranol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.

  • metaproterenol

    metaproterenol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • methyclothiazide

    methyclothiazide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • metolazone

    metolazone and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • metoprolol

    metoprolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • nabumetone

    nabumetone increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • nadolol

    nadolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • naproxen

    naproxen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • nebivolol

    nebivolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • nefazodone

    nefazodone will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • nicardipine

    nicardipine will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • nifedipine

    nifedipine will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • nilotinib

    nilotinib will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • norepinephrine

    norepinephrine and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • olmesartan

    olmesartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • onabotulinumtoxinA

    gentamicin increases effects of onabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Aminoglycosides may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects. .

  • oxaliplatin

    gentamicin and oxaliplatin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • oxaprozin

    oxaprozin increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • parecoxib

    parecoxib increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • penbutolol

    penbutolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • peramivir

    gentamicin increases levels of peramivir by decreasing renal clearance. Use Caution/Monitor. Caution when peramivir coadministered with nephrotoxic drugs.

  • phenobarbital

    phenobarbital will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • phenytoin

    phenytoin will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • pindolol

    pindolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • pirbuterol

    pirbuterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • piroxicam

    piroxicam increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • polymyxin B

    gentamicin and polymyxin B both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • potassium acid phosphate

    potassium acid phosphate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

  • potassium chloride

    potassium chloride increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

  • potassium citrate

    potassium citrate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

  • prabotulinumtoxinA

    gentamicin increases effects of prabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Aminoglycosides may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects. .

  • propranolol

    propranolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • quercetin

    quercetin will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • rifampin

    rifampin will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • rimabotulinumtoxinB

    gentamicin increases effects of rimabotulinumtoxinB by pharmacodynamic synergism. Use Caution/Monitor. Aminoglycosides may potentiate botulinum toxin effects, which may result in excessive neuromuscular weakness and heighten systemic anticholinergic effects. .

  • ritonavir

    ritonavir will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • sacubitril/valsartan

    sacubitril/valsartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • salicylates (non-asa)

    salicylates (non-asa) increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • salmeterol

    salmeterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • salsalate

    salsalate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • sirolimus

    sirolimus will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • sodium picosulfate/magnesium oxide/anhydrous citric acid

    gentamicin decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug.

  • sodium sulfate/?magnesium sulfate/potassium chloride

    sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of gentamicin by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol

    gentamicin and sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.

  • sodium sulfate/potassium sulfate/magnesium sulfate

    sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of gentamicin by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sotalol

    sotalol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • spironolactone

    spironolactone increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

  • St John's Wort

    St John's Wort will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • streptozocin

    gentamicin and streptozocin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • succinylcholine

    succinylcholine increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • sulfasalazine

    sulfasalazine increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • sulindac

    sulindac increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • tacrolimus

    tacrolimus will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.gentamicin and tacrolimus both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

  • teicoplanin

    gentamicin and teicoplanin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

  • telmisartan

    telmisartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • tenofovir DF

    gentamicin and tenofovir DF both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.gentamicin increases levels of tenofovir DF by decreasing elimination. Use Caution/Monitor.

  • terbutaline

    terbutaline and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • timolol

    timolol increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • tobramycin

    gentamicin and tobramycin both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor.

  • tobramycin inhaled

    tobramycin inhaled and gentamicin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicity

  • tolfenamic acid

    tolfenamic acid increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • tolmetin

    tolmetin increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • tolvaptan

    tolvaptan will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.tolvaptan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • torsemide

    torsemide and gentamicin both decrease serum potassium. Use Caution/Monitor.

  • trazodone

    trazodone will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • triamterene

    triamterene increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

  • trimagnesium citrate anhydrous

    gentamicin, trimagnesium citrate anhydrous.Either increases effects of the other by Other (see comment). Use Caution/Monitor. Comment: Coadministration of aminoglycosides with magnesium may increase risk of neuromuscular weakness and paralysis.

  • valsartan

    valsartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • verapamil

    verapamil will increase the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.

  • voclosporin

    voclosporin, gentamicin.Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.

  • aceclofenac

    aceclofenac increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • acemetacin

    acemetacin increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • adefovir

    adefovir and gentamicin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.

  • aspirin

    aspirin increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • aspirin rectal

    aspirin rectal increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • aspirin/citric acid/sodium bicarbonate

    aspirin/citric acid/sodium bicarbonate increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • aztreonam

    aztreonam, gentamicin.Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Combination may be used synergistically against Pseudomonas spp. and Enterobacteriaceae.

  • balsalazide

    gentamicin will decrease the level or effect of balsalazide by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

  • biotin

    gentamicin will decrease the level or effect of biotin by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

  • calcium acetate

    gentamicin decreases levels of calcium acetate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • calcium carbonate

    gentamicin decreases levels of calcium carbonate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • calcium chloride

    gentamicin decreases levels of calcium chloride by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • calcium citrate

    gentamicin decreases levels of calcium citrate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • calcium gluconate

    gentamicin decreases levels of calcium gluconate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • celecoxib

    celecoxib increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • choline magnesium trisalicylate

    choline magnesium trisalicylate increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • clotrimazole

    clotrimazole decreases levels of gentamicin by unknown mechanism. Minor/Significance Unknown.

  • cordyceps

    cordyceps decreases toxicity of gentamicin by unspecified interaction mechanism. Minor/Significance Unknown.

  • cyanocobalamin

    gentamicin decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • cytarabine

    cytarabine decreases effects of gentamicin by unspecified interaction mechanism. Minor/Significance Unknown.

  • diclofenac

    diclofenac increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • diflunisal

    diflunisal increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • entecavir

    gentamicin, entecavir.Either increases effects of the other by decreasing renal clearance. Minor/Significance Unknown. Coadministration with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of either entecavir or the coadministered drug.

  • etodolac

    etodolac increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • fenoprofen

    fenoprofen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • fluconazole

    fluconazole decreases levels of gentamicin by unknown mechanism. Minor/Significance Unknown.

  • flurbiprofen

    flurbiprofen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • foscarnet

    foscarnet and gentamicin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.

  • ibuprofen

    ibuprofen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • indomethacin

    indomethacin increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • ketoconazole

    ketoconazole decreases levels of gentamicin by unknown mechanism. Minor/Significance Unknown.

  • ketoprofen

    ketoprofen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • ketorolac

    ketorolac increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • ketorolac intranasal

    ketorolac intranasal increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • levoketoconazole

    levoketoconazole decreases levels of gentamicin by unknown mechanism. Minor/Significance Unknown.

  • lornoxicam

    lornoxicam increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • magnesium chloride

    gentamicin decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.

  • magnesium citrate

    gentamicin decreases levels of magnesium citrate by increasing renal clearance. Minor/Significance Unknown.

  • magnesium hydroxide

    gentamicin decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

  • magnesium oxide

    gentamicin decreases levels of magnesium oxide by increasing renal clearance. Minor/Significance Unknown.

  • magnesium sulfate

    gentamicin decreases levels of magnesium sulfate by increasing renal clearance. Minor/Significance Unknown.

  • meclizine

    meclizine, gentamicin. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Ototoxicity of aminoglycoside may be masked.

  • meclofenamate

    meclofenamate increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • mefenamic acid

    mefenamic acid increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • meloxicam

    meloxicam increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • methoxyflurane

    gentamicin and methoxyflurane both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.

  • miconazole vaginal

    miconazole vaginal decreases levels of gentamicin by unknown mechanism. Minor/Significance Unknown.

  • nabumetone

    nabumetone increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • naproxen

    naproxen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • noni juice

    noni juice increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

  • oxaprozin

    oxaprozin increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • pantothenic acid

    gentamicin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

  • parecoxib

    parecoxib increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • paromomycin

    gentamicin and paromomycin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.

  • pentamidine

    gentamicin and pentamidine both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.

  • perindopril

    perindopril, gentamicin. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Mfr. recommends using combination with caution (interaction not specified).

  • piperacillin

    piperacillin increases effects of gentamicin by pharmacodynamic synergism. Minor/Significance Unknown.

  • piroxicam

    piroxicam increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • posaconazole

    posaconazole decreases levels of gentamicin by unknown mechanism. Minor/Significance Unknown.

  • pyridoxine

    gentamicin will decrease the level or effect of pyridoxine by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

  • pyridoxine (Antidote)

    gentamicin will decrease the level or effect of pyridoxine (Antidote) by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

  • salicylates (non-asa)

    salicylates (non-asa) increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • salsalate

    salsalate increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • streptomycin

    gentamicin and streptomycin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.

  • sulfasalazine

    sulfasalazine increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • sulindac

    sulindac increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • thiamine

    gentamicin will decrease the level or effect of thiamine by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

  • tolfenamic acid

    tolfenamic acid increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • tolmetin

    tolmetin increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • vancomycin

    gentamicin and vancomycin both increase nephrotoxicity and/or ototoxicity. Minor/Significance Unknown.

  • voriconazole

    voriconazole decreases levels of gentamicin by unknown mechanism. Minor/Significance Unknown.

  • zoledronic acid

    gentamicin, zoledronic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Additive hypocalcemia.

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